Can you take ondansetron while pregnant?

Is ondansetron safe in first trimester of pregnancy?

A new study from Brigham and Women’s Hospital finds that pregnant women taking the common anti-nausea medication ondansetron during the first trimester have no increased risk of cardiac malformations and only a slight increased risk of oral clefts.

How much ondansetron is safe during pregnancy?

Typical dosage for pregnancy nausea

The dose of Zofran for hyperemesis gravidarum requiring hospitalization is a maximum of 10 milligrams via intravenous therapy (IV) every 8 hours. More typical pregnancy nausea is managed by a much lower oral dose — 4 to 8 mg every 8 hours.

Can ondansetron cause miscarriage?

Ondansetron used after around week 10 of pregnancy would not be able to cause these problems as the baby is fully developed by this stage. There are no concerns that ondansetron use in pregnancy affects the chance of miscarriage, stillbirth, preterm delivery or low infant birth weight.

Can ondansetron cause birth defects?

The results of these studies have concluded Zofran causes birth defects, particularly congenital heart defects, cleft palate defects, and kidney defects. The birth defects linked to use of Zofran during pregnancy include: 130% risk of overall birth defects.

Will taking Zofran hurt my baby?

If you are pregnant and have taken ondansetron or Zofran® during pregnancy, I want to reassure you that it likely has not affected your baby. Even if the increased risk for cleft palate or heart defects turns out to be true, the risk to your baby is still very, very small.

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What is the best nausea medicine for pregnancy?

In fact, the FDA has approved a prescription medication for use during pregnancy that is a combination of Vitamin B6 and Unisom. It is called Diclegis. This is the only FDA approved medication for treating nausea and vomiting during pregnancy.

What pregnancy category is ondansetron?

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Does ondansetron work for morning sickness?

Ondansetron (Zofran®) is a medicine used to treat nausea and vomiting that may be caused by surgery, chemotherapy, or radiation therapy. Healthcare professionals also prescribe ondansetron during pregnancy to reduce symptoms of nausea and vomiting, also known as “morning sickness.”

Is ondansetron safe in pregnancy NHS?

There are no concerns that ondansetron use in pregnancy affects the chance of miscarriage, stillbirth, preterm delivery or low infant birth weight.

Does ondansetron cross the placenta?

Based on the findings of our analysis, ondansetron dosing does not need to be altered in pregnancy, and it readily crosses the placenta. However, a dosage adjustment is required in neonates because of its longer half-life, which is likely to be due to reduced clearance.