Which of the following antibiotics is responsible for gray baby syndrome?
Gray baby syndrome: A syndrome due to toxicity of the antibiotic chloramphenicol in the newborn, especially the premature newborn, because of lack the necessary liver enzymes to metabolize this drug.
Why did infants develop gray syndrome when given chloramphenicol?
Insufficient metabolism and excretion of chloramphenicol leads to increased blood concentrations of the drug, causing blockade of the electron transport of the liver, myocardium, and skeletal muscles. Since the electron transport is an essential part of cellular respiration, its blockade can result in cell damage.
Why chloramphenicol is contraindicated in pediatrics?
The other major toxic effect of chloramphenicol is the gray baby syndrome in neonates, which is characterized by abdominal distension, vomiting, flaccidity, cyanosis, circulatory collapse, and death. This syndrome also has been recognized in toddlers and after overdoses in adults.
What medication is indicated in serious life threatening infections and has adverse effects of bone marrow suppression and gray baby syndrome?
 However, chloramphenicol is a rarely used drug in the United States because of its known severe adverse effects, such as bone marrow toxicity and grey baby syndrome.
What is the most toxic reaction to chloramphenicol?
The most serious adverse effect of chloramphenicol is bone marrow depression. Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia) are known to occur after the administration of chloramphenicol.
What is red baby syndrome?
Red Baby Syndrome is a new disease seen in infants and young children. Dramatic onset of clinical symptoms with high intensity, short duration and lack of similarity with other cutaneous lesions makes it distinct. Of 50 such patients studied over a period of 5 years, half were below one year of age.
What is the GREY baby syndrome?
Gray baby syndrome is a condition in which an infant experiences a life-threatening reaction to the antibiotic Chloramphenicol. It is more prevalent in premature infants since an adverse reaction is directly related to the liver’s ability to break down and process the medication.
What is the mechanism of action for chloramphenicol?
Chloramphenicol is an antibacterial agent with a broad spectrum of activity against gram-positive bacteria, gram-negative bacteria, and Rickettsia. Its mechanism of action is by inhibition of bacterial protein synthesis by binding with ribosomes.